Variation
4 pieces tagged Variation.
The Dismal Disease: Temozolomide and the Interaction of Evidence
Evidence interacts. To understand the evidence base for an intervention we must look not only at individual studies, but the relationships between them.
The Avoidable Scandal: Benoxaprofen and Theories of Medical Evidence
Benoxaprofen, marketed as Opren in the UK, created a scandal in 1982 when it was withdrawn from sale amidst reports of over 60 deaths and thousands of adverse reactions. The question of who was at fault for this disaster has been addressed many times in the academic...
UBL and Variation
I've argued that information about variation in treatment effects is vital for doctors, patients and regulators alike. This information does not come from RCTs. Nonetheless, we can acquire high-quality, compelling evidence of variation. The case studies I've presented in the...
Two Dogmas of Evidence Hierarchies
Hierarchies of evidence in Evidence-Based Medicine (EBM) come in many varieties and have been very influential in medical practice and policy since the late 1990s. However, two fundamental problematic assumptions underpin the use of hierarchies of any kind in clinical...